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    Irst research that comprehensively examine how parental attachment influences PIU, this study will contribute to a deeper understanding from the varying impacts on the two dimensions of attachment style as well as the gender difference in how maternal and paternal attachments can predict PIU in males and females. Even so, it can be crucial to acknowledge that cross-sectional studies like this one usually do not establish causality. Although the sample size is enough for the analyses in this study, it really is admittedly fpsyg.2016.01448 not large. Achievable confounding factors like neuroticism really should also be controlled in future function. We definitely require followup analysis to replicate these findings and examine the influence of attainable moderating and mediating variables to achieve a deeper understanding in the phenomenon. It is actually our hope that this study stimulates further advancement within this area of work.Funding sources: No monetary help was received for this study. Authors’ contribution: RJ and HHJ contributed in all elements of the study. Both authors have full access to all information in the study and take full duty of its integrity and accuracy. Conflict of interest: The authors declare no conflict of interest.Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Post ID 425476, 15 pages doi:10.1155/2012/Review Short article Dendritic Cells The Tumor Microenvironment as well as the Challenges for an efficient fnins.2013.00251 Antitumor VaccinationFabian Benencia,1, two, three Leslee Sprague,1 John Title Loaded From File McGinty,three Michelle Pate,3 and Maria Muccioli1 Biomedical 2 MolecularEngineering Plan, Russ College of Engineering and Technology, Ohio University, Athens, OH 45701-2979, USA and Cellular Biology Program, Ohio University, Athens, OH 45701-2979, USA 3 Division of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA Correspondence must be addressed to Fabian Benencia, benencia@oucom.ohiou.edu Received 15 August 2011; Revised 28 October 2011; Accepted 11 November 2011 Academic Editor: Wolfgang Herr Copyright ?2012 Fabian Benencia et al. This can be an open access write-up distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original operate is effectively cited. A lot of clinical trials have already been carried out or are in progress to assess the therapeutic possible of dendritic-cell- (DC-) primarily based vaccines on cancer sufferers, and recently the very first DC-based vaccine for human cancer was authorized by the FDA. Herewith, we describe the common characteristics of DCs and unique strategies to generate productive antitumor DC vaccines. In recent years, the relevance with the tumor microenvironment within the progression of cancer has been highlighted. It has been shown that the tumor microenvironment is capable of inactivating different elements in the immune program accountable for tumor clearance. In unique, the impact from the tumor microenvironment on antigen-presenting cells, for instance DCs, does not only render these immune cells unable to induce specific immune responses, but in addition turns them into promoters of tumor growth. We also describe techniques probably to improve the efficacy of DC vaccines by reprogramming the immunosuppressive nature of your tumor microenvironment.1. General Traits of Dendritic CellsDendritic cells (DCs) are specialist antigen-presenting cells (APCs) found in peripheral tissues and in immunological organs such.